Metabolism of alpha-hexachlorocyclohexane. Free metabolites in urine and organs of rats

Xenobiotica. 1982 Apr;12(4):227-31. doi: 10.3109/00498258209052460.


k1. The alpha-isomer of 1,2,3,4,5,6-hexachlorocyclohexane (HCH) is converted in rats to 1,2,4-trichlorobenzene, 2,3,4-trichlorophenol, 2,4,6-trichlorophenol, other trichlorophenols, and 2,3,4,6-tetrachlorophenol, which were excreted in urine. 2. Alpha-HCH is also converted to 3,4,6/5-pentachlorocyclohexene which is detectable in kidneys, but not in urine. 3. The results of this study are discussed with references to earlier work and to gamma-HCH metabolism.

MeSH terms

  • Animals
  • Chromatography, Gas
  • Hexachlorocyclohexane / metabolism*
  • Hexachlorocyclohexane / urine
  • Male
  • Mass Spectrometry
  • Rats
  • Rats, Inbred Strains
  • Tissue Distribution


  • Hexachlorocyclohexane