Homogeneous interferon from E. coli depresses hepatic cytochrome P-450 and drug biotransformation

Biochem Biophys Res Commun. 1982 Jun 30;106(4):1256-61. doi: 10.1016/0006-291x(82)91247-5.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biotransformation
  • Cloning, Molecular*
  • Cytochrome P-450 Enzyme System / biosynthesis*
  • DNA, Recombinant / metabolism
  • Escherichia coli / genetics*
  • Humans
  • Interferons / genetics
  • Interferons / pharmacology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / metabolism*
  • Poly I-C / pharmacology

Substances

  • DNA, Recombinant
  • Interferons
  • Cytochrome P-450 Enzyme System
  • Poly I-C