Muscle protein synthesis measured by stable isotope techniques in man: the effects of feeding and fasting

Clin Sci (Lond). 1982 Dec;63(6):519-23. doi: 10.1042/cs0630519.


1. Measurements have been made of whole-body and skeletal muscle protein synthesis in fed and fasted adults with L-[1-13C]leucine. 2. The marked increase in whole-body synthesis on feeding largely reflects the changes in protein synthesis in muscle, which doubles on feeding, compared with a 40% increase in that of the rest of the body. 3. Skeletal muscle in fed man contributes more than half to total protein synthesis occurring in the whole body.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Carbon Dioxide / blood
  • Carbon Isotopes
  • Eating*
  • Fasting*
  • Humans
  • Keto Acids / blood
  • Leucine / metabolism
  • Male
  • Middle Aged
  • Muscle Proteins / biosynthesis*
  • RNA / metabolism


  • Carbon Isotopes
  • Keto Acids
  • Muscle Proteins
  • Carbon Dioxide
  • RNA
  • alpha-ketoisocaproic acid
  • Leucine