B cell function in patients with chronic pancreatitis and its relation to exocrine pancreatic function

Diabetologia. 1982 Aug;23(2):86-9. doi: 10.1007/BF01271165.


Exocrine pancreatic function was evaluated by a Lundh meal test and a secretin-cholecystokinin test in 16 patients with chronic pancreatitis. B cell function was assessed by measuring the concentration of C-peptide after stimulation with oral glucose and intravenous glucagon. The Cc-peptide response to intravenous glucagon and oral glucose was closely correlated (r = 0.88, p less than 0.01). Plasma C-peptide after glucagon was significantly correlated to the post-prandial concentration of lipase (r = 0.72, p less than 0.001), amylase (r = 0.64, p less than 0.05) and to amylase output (r = 0.64, p less than 0.05). Eight out of nine patients treated with insulin had residual B cell function, but it diminished significantly with increasing duration of diabetes. We conclude that B cell function is correlated to pancreatic enzyme secretion and that patients with insulin-treated diabetes secondary to chronic pancreatitis have a residual insulin secretion similar to that of patients with Type 1 (insulin-dependent) diabetes.

MeSH terms

  • Adult
  • Aged
  • Amylases / metabolism
  • Bicarbonates / metabolism
  • C-Peptide / blood
  • Chronic Disease
  • Female
  • Glucagon
  • Glucose Tolerance Test
  • Humans
  • Islets of Langerhans / metabolism*
  • Lipase / metabolism
  • Male
  • Middle Aged
  • Pancreas / metabolism
  • Pancreatic Function Tests
  • Pancreatitis / physiopathology*


  • Bicarbonates
  • C-Peptide
  • Glucagon
  • Lipase
  • Amylases