Effects of levamisole on human natural killer and killer cell activity and production of interferons

Immunopharmacology. 1982 Oct;5(1):11-8. doi: 10.1016/0162-3109(82)90032-7.


The effect of levamisole on natural killer (NK) and killer (K) cell activities and on interferon production was determined in both normal subjects and cancer patients. Levamisole had no effect on these cytolytic immune effector cells in vitro. It did not induce interferon production. Sequential determinations of NK cell activity and interferon plasma levels after single oral doses of levamisole failed to demonstrate an effect of levamisole on spontaneous cytotoxicity or interferon production.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Antibody-Dependent Cell Cytotoxicity / drug effects
  • Cytotoxicity, Immunologic / drug effects*
  • Humans
  • Immunity, Cellular / drug effects
  • Interferons / biosynthesis*
  • Interferons / blood
  • Killer Cells, Natural / immunology*
  • Levamisole / pharmacology*
  • Macrophages / immunology


  • Levamisole
  • Interferons