Primary structure of alpha-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

Nature. 1982 Oct 28;299(5886):793-7. doi: 10.1038/299793a0.


DNA sequences complementary to the Torpedo californica electroplax mRNA coding for the alpha-subunit precursor of the acetylcholine receptor were cloned. The nucleotide sequence of the cloned cDNA indicates that the precursor consists of 461 amino acids including a prepeptide of 24 amino acids. Possible sites for acetylcholine binding and antigenic determinants on the alpha-subunit molecule are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA
  • Epitopes
  • RNA, Messenger
  • Receptors, Cholinergic / genetics*
  • Torpedo / genetics*


  • Epitopes
  • RNA, Messenger
  • Receptors, Cholinergic
  • DNA

Associated data

  • GENBANK/J00963
  • GENBANK/M14810