Abnormal immune response to brain tissue antigen in the syndrome of autism

Am J Psychiatry. 1982 Nov;139(11):1462-5. doi: 10.1176/ajp.139.11.1462.


Cell-mediated immune response to human myelin basic protein was studied by the macrophage migration inhibition factor test in 17 autistic patients and a control group of 11 patients suffering from other mental diseases included in the differential diagnosis of the syndrome of autism. Of the 17 autistic patients, 13 demonstrated inhibition of macrophage migration, whereas none of the nonautistic patients showed such a response. The results indicate the existence of a cell-mediated immune response to brain tissue in the syndrome of autism.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Autistic Disorder / immunology*
  • Brain / immunology*
  • Cell Migration Inhibition
  • Child
  • Female
  • Humans
  • Intellectual Disability / immunology
  • Macrophage Migration-Inhibitory Factors / immunology
  • Macrophages / immunology
  • Male
  • Myelin Basic Protein / immunology*
  • Schizophrenia, Childhood / immunology


  • Macrophage Migration-Inhibitory Factors
  • Myelin Basic Protein