Histologic observations of variably acid-fast pleomorphic bacteria in systemic sarcoidosis: a report of 3 cases

Growth. Summer 1982;46(2):113-25.


Tissue sections of skin and lymph nodes from three consecutively diagnosed cases of systemic sarcoidosis were studied for the presence of acid-fast bacteria, utilizing routine and acid-fast staining techniques recently recommended for the demonstration of cell-wall-deficient bacteria (L-forms). Evidence of variably acid-fast cocco-bacillary forms was present within the biopsy material of all the patients. The combined findings of variably sized, predominantly coccoid forms, along with larger forms resembling L-form "large bodies," and short acid-fast rods all suggest that cell-wall-deficient bacteria (possibly related to the mycobacteria or corynebacteria) may be present in cases of sarcoidosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Corynebacterium / cytology
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • L Forms / cytology*
  • Lymph Nodes / microbiology
  • Male
  • Middle Aged
  • Mycobacterium / cytology
  • Sarcoidosis / microbiology*
  • Sarcoidosis / pathology
  • Skin / microbiology
  • Staining and Labeling