The effect of carbachol and isoprenaline on cell division in the exocrine pancreas of the rat

Q J Exp Physiol. 1982 Oct;67(4):577-85. doi: 10.1113/expphysiol.1982.sp002677.


The effect of muscarinic cholinergic receptor stimulation on pancreatic acinar cell division has been investigated. Muscarinic receptor stimulation, in addition to causing a 50% depletion of amylase in the pancreas after 4 h, resulted in a 400% increase in the incorporation of [6(-3)H]thymidine 27 h after drug administration. This increase in incorporation was dose-dependent. Autoradiography showed this increase to be due to an increased acinar cell labelling. Isoprenaline also increased the incorporation of [6(-3)H]thymidine into the pancreas but did not reduce enzyme levels. However, with isoprenaline there was no increase in acinar cell labelling. The possibility of a relationship between secretion and hyperplasia of acinar cells in the rat pancreas is discussed.

Publication types

  • Comparative Study

MeSH terms

  • Amylases / metabolism
  • Animals
  • Carbachol / pharmacology*
  • Cell Division / drug effects
  • DNA / biosynthesis
  • Hyperplasia
  • Isoproterenol / pharmacology*
  • Male
  • Pancreas / cytology
  • Pancreas / drug effects*
  • Pancreas / metabolism
  • Rats
  • Rats, Inbred Strains
  • Receptors, Muscarinic / drug effects


  • Receptors, Muscarinic
  • Carbachol
  • DNA
  • Amylases
  • Isoproterenol