Cerebrospinal fluid proteins and cells in normal-pressure hydrocephalus

J Neurol. 1982;228(3):171-80. doi: 10.1007/BF00313729.


A total of 21 patients with normal-pressure hydrocephalus were examined. Cerebrospinal fluid (CSF) was collected before and after operation with a ventriculoperitoneal shunt. A slight plasma-like protein pattern indicating a blood-brain barrier (BBB) dysfunction was seen in 38% of the patients before operation. No characteristic changes could be found in the "CSF-specific" protein fraction. After the shunt operation 65% of the patients had a BBB dysfunction to macromolecules and 70% had two additional acidic protein bands in the CSF-specific fraction. Ventricular CSF protein content was 73% of lumbar CSF content when shunts were patent. Isotope encephalography showed a radionuclide accumulation at the intracranial part of the shunt system, indicating that the BBB damage might be located round the shunt catheter.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood-Brain Barrier
  • Cerebrospinal Fluid / cytology*
  • Cerebrospinal Fluid Proteins / analysis*
  • Chromatography, Affinity
  • Electrophoresis, Agar Gel
  • Humans
  • Hydrocephalus / cerebrospinal fluid*
  • Hydrocephalus, Normal Pressure / cerebrospinal fluid*
  • Hydrocephalus, Normal Pressure / diagnostic imaging
  • Hydrocephalus, Normal Pressure / physiopathology
  • Isoelectric Focusing
  • Radionuclide Imaging


  • Cerebrospinal Fluid Proteins