Location and primary structure of a major antigenic site for poliovirus neutralization

Nature. 1983 Feb 24;301(5902):674-9. doi: 10.1038/301674a0.

Abstract

We have determined a major antigenic site for virus neutralization on the capsid protein VP1 of poliovirus type 3. Antigenic mutant viruses selected for resistance to individual monoclonal antibodies had point mutations concentrated in a region 277-294 bases downstream from the start of the region of viral RNA coding for VP1. These findings provide the basis for an improved understanding of the molecular basis of virus neutralization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antibodies, Monoclonal
  • Antigens, Viral* / genetics
  • Base Sequence
  • Capsid / immunology*
  • Epitopes
  • Genes, Viral
  • Mutation
  • Poliovirus / genetics
  • Poliovirus / immunology*
  • RNA, Viral / genetics
  • Viral Proteins / immunology*

Substances

  • Antibodies, Monoclonal
  • Antigens, Viral
  • Epitopes
  • RNA, Viral
  • Viral Proteins

Associated data

  • GENBANK/J02284