Abstract
The lysis of SV40-transformed target cells by a cloned cytotoxic T cell line (CTB6) that is SV40 TASA-specific and H-2Kb-restricted is blocked by a monoclonal antibody reactive with the SV40 T-antigen. The blocking is maximized at high antibody concentrations and low effector-to-target cell ratios. These data indicate that at least one antigenic determinant of the SV40 T-antigen molecule is expressed at the cell surface and is either recognized by this cytotoxic T lymphocyte or is proximate to that determinant recognized by this cytotoxic T lymphocyte.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal
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Antibodies, Viral
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Antigens, Neoplasm / immunology*
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Antigens, Viral / immunology*
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Antigens, Viral, Tumor
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Cell Line
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Cell Transformation, Viral
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Cytotoxicity, Immunologic*
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Epitopes
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Histocompatibility Antigens / immunology*
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Mice
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Simian virus 40 / immunology
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Simian virus 40 / physiology*
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T-Lymphocytes, Cytotoxic / immunology*
Substances
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Antibodies, Monoclonal
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Antibodies, Viral
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Antigens, Neoplasm
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Antigens, Viral
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Antigens, Viral, Tumor
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Epitopes
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Histocompatibility Antigens
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tumor-associated transplantation antigen