Monoclonal antibody to SV40 T-antigen blocks lysis of cloned cytotoxic T-cell line specific for SV40 TASA

Virology. 1983 Feb;125(1):1-7. doi: 10.1016/0042-6822(83)90058-2.

Abstract

The lysis of SV40-transformed target cells by a cloned cytotoxic T cell line (CTB6) that is SV40 TASA-specific and H-2Kb-restricted is blocked by a monoclonal antibody reactive with the SV40 T-antigen. The blocking is maximized at high antibody concentrations and low effector-to-target cell ratios. These data indicate that at least one antigenic determinant of the SV40 T-antigen molecule is expressed at the cell surface and is either recognized by this cytotoxic T lymphocyte or is proximate to that determinant recognized by this cytotoxic T lymphocyte.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Antibodies, Viral
  • Antigens, Neoplasm / immunology*
  • Antigens, Viral / immunology*
  • Antigens, Viral, Tumor
  • Cell Line
  • Cell Transformation, Viral
  • Cytotoxicity, Immunologic*
  • Epitopes
  • Histocompatibility Antigens / immunology*
  • Mice
  • Simian virus 40 / immunology
  • Simian virus 40 / physiology*
  • T-Lymphocytes, Cytotoxic / immunology*

Substances

  • Antibodies, Monoclonal
  • Antibodies, Viral
  • Antigens, Neoplasm
  • Antigens, Viral
  • Antigens, Viral, Tumor
  • Epitopes
  • Histocompatibility Antigens
  • tumor-associated transplantation antigen