The effect of McN-A-343 on muscarinic receptors in the cerebral cortex and heart

Br J Pharmacol. 1983 Feb;78(2):257-9. doi: 10.1111/j.1476-5381.1983.tb09388.x.


McN-A-343 behaves as a competitive agonist in binding to muscarinic receptors in the cerebral cortex. In its interaction with myocardial muscarinic receptors it is not competitive but it retains features of agonist binding.

MeSH terms

  • (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride / pharmacology*
  • Animals
  • Binding, Competitive
  • Cerebral Cortex / drug effects*
  • Heart / drug effects*
  • In Vitro Techniques
  • Quaternary Ammonium Compounds / pharmacology*
  • Rats
  • Receptors, Cholinergic / drug effects*
  • Receptors, Muscarinic / drug effects*


  • Quaternary Ammonium Compounds
  • Receptors, Cholinergic
  • Receptors, Muscarinic
  • (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride