Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosome

Nature. 1983 Mar 24-30;302(5906):346-9. doi: 10.1038/302346a0.


The mammalian sex chromosomes are thought to be related to each other by sharing a common origin. That is, the X and Y chromosomes originally evolved from a pair of chromosomes that only differed at the locus determining sexual differentiation. For example, this evolutionary relationship is reflected during meiosis in chromosomal pairing between the tip of the human X chromosome short arm and the Y chromosome which presumably implies sequence homology. However, compelling genetic evidence for functional homology between the mammalian X and Y chromosome is lacking. We describe here the localization of a gene to the tip of the short arm of the human X chromosome and evidence for a related gene on the Y chromosome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Antibodies, Monoclonal
  • Antigens, Surface / genetics
  • Biological Evolution
  • Epitopes
  • Female
  • Genetic Linkage
  • Humans
  • Male
  • Polymorphism, Genetic
  • Sex Chromosomes / physiology*
  • X Chromosome / physiology*
  • Y Chromosome / physiology*


  • Antibodies, Monoclonal
  • Antigens, Surface
  • Epitopes