Effects of prednisolone and medroxyprogesterone on corneal wound healing, ulceration, and neovascularization

Arch Ophthalmol. 1983 Apr;101(4):640-3. doi: 10.1001/archopht.1983.01040010640024.


Albino rabbits were treated four or six times daily with 1% prednisolone acetate, 1% medroxyprogesterone acetate, or a control vehicle, after one of three conditions. First, after 3-mm linear perforating stromal incisions; drugs were given for seven days, and wound bursting strength was determined. Prednisolone suppressed wound tensile strength by 20%; medroxyprogesterone suppressed it by 11%. Second, after trephination, drug administration for 14 days decreased collagen formation in the scar buttons by 43% in the prednisolone-treated group and 39% in the medroxy-progesterone-treated group. Third, after thermal burns; when drug application followed the burn immediately, deep ulceration or perforation developed in 85% of the controls, in none of the prednisolone-treated group, and in 17% of the medroxyprogesterone-treated group. When drug delivery was withheld until day 6, severe ulceration developed in 44% of both groups. In both experiments, stromal neovascularization was markedly suppressed by prednisolone, but only moderately decreased by medroxyprogesterone.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Collagen / metabolism
  • Cornea / blood supply
  • Cornea / metabolism
  • Corneal Injuries*
  • Corneal Ulcer / drug therapy*
  • Medroxyprogesterone / administration & dosage
  • Medroxyprogesterone / analogs & derivatives*
  • Medroxyprogesterone / pharmacology
  • Medroxyprogesterone Acetate
  • Neovascularization, Pathologic*
  • Prednisolone / administration & dosage
  • Prednisolone / analogs & derivatives*
  • Prednisolone / pharmacology
  • Rabbits
  • Wound Healing / drug effects*


  • prednisolone acetate
  • Collagen
  • Prednisolone
  • Medroxyprogesterone Acetate
  • Medroxyprogesterone