Potentiating effects of oxygen in lungs damaged by methylcyclopentadienyl manganese tricarbonyl, cadmium chloride, oleic acid, and antitumor drugs

Toxicol Appl Pharmacol. 1983 Jan;67(1):55-69. doi: 10.1016/0041-008x(83)90244-2.


The intraperitoneal administration of methylcyclopentadienyl manganese tricarbonyl (MMT) and cyclophosphamide, exposure to an aerosol of cadmium chloride, intravenous administration of oleic acid, and intratracheal instillation of bleomycin to young female BALB/c mice or CD/CR rats result in acute lung injury. Pulmonary morphology and lung collagen content were examined in animals treated with these chemicals alone or in combination with an elevated oxygen concentration (80%) in the inspired air. In mice, the development of fibrosis could be significantly enhanced if animals treated with MMT, cadmium chloride, cyclophosphamide, or bleomycin were exposed to 80% oxygen immediately following exposure to these agents. In rats only cyclophosphamide- and bleomycin-induced acute lung injury was potentiated by hyperoxia, resulting in significant enhancement of lung collagen content. The pathogenesis responsible for this differential species response of pulmonary injury to hyperoxia remains to be investigated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents / toxicity*
  • Bleomycin / toxicity
  • Butylated Hydroxytoluene / toxicity
  • Cadmium / toxicity*
  • Cadmium Chloride
  • Cyclophosphamide / toxicity
  • Drug Synergism
  • Female
  • Humans
  • Hyaline Membrane Disease / chemically induced
  • Hydroxyproline / analysis
  • Infant, Newborn
  • Lung / analysis
  • Lung / drug effects*
  • Manganese Poisoning*
  • Mice
  • Mice, Inbred BALB C
  • Oleic Acids / toxicity*
  • Organometallic Compounds / toxicity*
  • Oxygen / toxicity*
  • Rats
  • Rats, Inbred Strains
  • Species Specificity


  • Antineoplastic Agents
  • Oleic Acids
  • Organometallic Compounds
  • Cadmium
  • Bleomycin
  • 2-methylcyclopentadienyl manganese tricarbonyl
  • Butylated Hydroxytoluene
  • Cyclophosphamide
  • Cadmium Chloride
  • Hydroxyproline
  • Oxygen