Cross-reactions in the HLA system revealed by red blood cells expressing HLA determinants, with particular reference to cross-reaction between HLA-A2 and B17

Vox Sang. 1983;44(4):218-24. doi: 10.1111/j.1423-0410.1983.tb01887.x.

Abstract

Sera with cytotoxic and haemagglutinating activity towards HLA-A2/28 were also shown to react with red blood cells (RBC) expressing the HLA-B17 antigen determinant. Absorption procedures with white blood cells (WBC) indicated that this was due to an HLA-A2/B17 cross-reaction. Absorption experiments with some other sera which previously had shown cytotoxic and haemagglutinating activity towards different HLA specificities, revealed broad cross-reaction related to HLA-B locus antigens.

MeSH terms

  • Cross Reactions
  • Cytotoxicity, Immunologic
  • Epitopes
  • Erythrocyte Membrane / immunology*
  • Erythrocytes / immunology*
  • HLA Antigens / immunology*
  • HLA-A2 Antigen
  • HLA-B Antigens
  • Hemagglutination
  • Humans

Substances

  • Epitopes
  • HLA Antigens
  • HLA-A2 Antigen
  • HLA-B Antigens