Abstract
The present studies have shown that chronic antidepressant treatment with desipramine, imipramine, zimelidine and alaproclate led to adaptive changes in both pre- and postsynaptic 5-hydroxytryptamine (5-HT) receptor mechanisms which appear to result in 5-HT sub- or supersensitivity development depending upon the 5-HT nerve terminal systems analyzed. The results underline the heterogeneity of the central 5-HT neurone systems in their responses to chronic antidepressant treatment. An involvement of 5-HT comodulators is postulated in the actions of antidepressants on central 5-HT synapses. Finally, the results point to the importance of 5-HT neurone systems as targets for the action for antidepressant drugs and they may mediate at least some of the therapeutic activity of antidepressant drugs.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antidepressive Agents / pharmacology*
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Carrier Proteins*
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Corticosterone / metabolism
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Cyclic AMP / metabolism
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Dihydroalprenolol / metabolism
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Hippocampus / metabolism
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Humans
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Imipramine / metabolism
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Lysergic Acid Diethylamide / metabolism
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Pituitary Hormones, Anterior / metabolism
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Receptors, Drug*
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Receptors, Neurotransmitter / analysis
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Receptors, Serotonin / analysis
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Receptors, Serotonin / drug effects*
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Serotonin / metabolism
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Spiperone / metabolism
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Substance P / pharmacology
Substances
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Antidepressive Agents
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Carrier Proteins
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Pituitary Hormones, Anterior
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Receptors, Drug
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Receptors, Neurotransmitter
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Receptors, Serotonin
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imipramine receptor
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Serotonin
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Substance P
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Spiperone
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Dihydroalprenolol
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Lysergic Acid Diethylamide
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Cyclic AMP
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Imipramine
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Corticosterone