Fetal sex-related differences in maternal serum alpha-fetoprotein during the second trimester of pregnancy

Am J Obstet Gynecol. 1983 Aug 1;146(7):786-9. doi: 10.1016/0002-9378(83)91078-5.

Abstract

In an analysis of data gathered from routine maternal serum alpha-fetoprotein screening, we determined that the sex of the fetus is significantly correlated with differences in maternal serum alpha-fetoprotein concentration during the second trimester of pregnancy. Between the fifteenth and nineteenth gestational weeks, the mean maternal serum alpha-fetoprotein level is significantly higher for the male fetus than for the female fetus. There was no difference, however, in the rate of increase in maternal serum alpha-fetoprotein concentration with time between male and female fetuses during the weeks of gestation that were studied. No apparent cause for these observations has been demonstrated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Body Weight
  • Female
  • Fetus / physiology*
  • Gestational Age
  • Humans
  • Male
  • Pregnancy
  • Pregnancy Trimester, Second
  • Prenatal Diagnosis
  • Reference Values
  • Retrospective Studies
  • Risk
  • Sex Determination Analysis*
  • Sex Factors
  • alpha-Fetoproteins / analysis*

Substances

  • alpha-Fetoproteins