Agents that increase cellular cAMP inhibit production of interleukin-2, but not its activity

Biochem Biophys Res Commun. 1983 Jul 18;114(1):93-8. doi: 10.1016/0006-291x(83)91598-x.

Abstract

Proliferation of lectin-treated mouse thymocytes induced by the tumor promoter, 12-0-tetradecanoyl-13-acetate, is markedly inhibited by cAMP analogues, prostaglandin E and methylisobutylxanthine. Proliferation induced by interleukin-2 is resistant to inhibition by these compounds. The tumor promoter induces interleukin-2 production in a subpopulation of lectin-treated thymocytes, and production of this lymphokine is inhibited by agents that increase cellular cAMP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Methyl-3-isobutylxanthine / pharmacology*
  • Alprostadil
  • Animals
  • Cyclic AMP / metabolism*
  • Cytotoxicity, Immunologic / drug effects
  • Interleukin-2 / biosynthesis
  • Interleukin-2 / physiology*
  • Kinetics
  • Lymphocytes / drug effects
  • Lymphocytes / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Phorbols / pharmacology*
  • Prostaglandins E / pharmacology*
  • Tetradecanoylphorbol Acetate / pharmacology*
  • Theophylline / analogs & derivatives*
  • Thymus Gland / immunology

Substances

  • Interleukin-2
  • Phorbols
  • Prostaglandins E
  • Theophylline
  • Cyclic AMP
  • Alprostadil
  • Tetradecanoylphorbol Acetate
  • 1-Methyl-3-isobutylxanthine