Immunoglobulin-deficient rats fail to develop experimental allergic encephalomyelitis

J Neuroimmunol. 1983 Oct;5(2):99-109. doi: 10.1016/0165-5728(83)90001-2.


Lewis rats were treated from day of birth with a rabbit anti-rat IgM antiserum. As adults these animals were found to have no detectable serum IgM and greatly reduced levels of IgG. They failed to respond to the B-cell mitogen LPS, or to make antibodies to sheep red blood cells (SRBC) or myelin basic protein (BP). These B-lymphocyte and immunoglobulin-deficient rats failed to develop clinical or histological evidence of EAE when sensitized with either whole spinal cord or purified BP. That some T-cell functions of these suppressed animals were not altered was seen by their ability to respond normally to PHA and to reject tissue allografts. The results would suggest that B-cell function (immunoglobulin-antibody production) is essential for the induction of EAE.

MeSH terms

  • Agammaglobulinemia / complications
  • Agammaglobulinemia / immunology*
  • Animals
  • Antibodies, Anti-Idiotypic / administration & dosage
  • B-Lymphocytes / immunology
  • Encephalomyelitis, Autoimmune, Experimental / etiology
  • Encephalomyelitis, Autoimmune, Experimental / immunology*
  • Freund's Adjuvant / administration & dosage
  • Immunoglobulin M / deficiency*
  • Immunoglobulin M / immunology
  • Immunosuppression
  • Lymphocyte Activation
  • Myelin Basic Protein / administration & dosage
  • Myelin Basic Protein / immunology
  • Nerve Tissue Proteins / administration & dosage
  • Rabbits
  • Rats
  • Rats, Inbred Lew


  • Antibodies, Anti-Idiotypic
  • Immunoglobulin M
  • Myelin Basic Protein
  • Nerve Tissue Proteins
  • spinal cord protein, Bos taurus
  • Freund's Adjuvant