Maculotoxin: a neurotoxin from the venom glands of the octopus Hapalochlaena maculosa identified as tetrodotoxin

Science. 1978 Jan 13;199(4325):188-9. doi: 10.1126/science.619451.


Maculotoxin, a potent neurotoxin isolated from the posterior salivary glands of the blue-ringed octopus. Hapalochlaena maculosa, has now been identified as tetrodotoxin. This is the first reported case in which tetrodotoxin has been found to occur in a venom.

MeSH terms

  • Animals
  • Mollusk Venoms / isolation & purification*
  • Octopodiformes / analysis*
  • Salivary Glands / analysis
  • Tetrodotoxin / isolation & purification*


  • Mollusk Venoms
  • Tetrodotoxin