Comparison of in vivo and in vitro responses to histamine in human airways

Am Rev Respir Dis. 1983 Nov;128(5):875-9. doi: 10.1164/arrd.1983.128.5.875.


The study was designed to compare in vivo responses to histamine in 14 patients prior to thoracotomy with in vitro responses to histamine of both parenchymal and bronchial tissue. Although a wide range of responsiveness occurred in vivo, as measured by the histamine inhalation test, the variation in the in vitro dose-response curves was negligible. There was no correlation between the dose of histamine that resulted in a 20% reduction in forced expiratory volume in one second and the concentration of histamine producing 50% of the maximal response in vitro. These findings raise the possibility that airway hyperresponsiveness may not result from an intrinsic abnormality of airway smooth muscle.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Bronchi / physiology*
  • Female
  • Histamine Release*
  • Humans
  • Lung / physiology*
  • Male
  • Middle Aged