Association of HLA-DR4/Dw4 and DR2/Dw2 with radiologic changes in a prospective study of patients with rheumatoid arthritis. Preferential relationship with HLA-Dw rather than HLA-DR specificities

Arthritis Rheum. 1984 Jan;27(1):20-5. doi: 10.1002/art.1780270104.


Patients admitted to a prospective study within a year of onset of suspected rheumatoid arthritis showed a positive correlation between HLA-Dw4 and the eventual severity of peripheral radiologic changes. Dw4 and DR4 were strongly associated with severity of erosions when analysis was restricted to each of the following: patients with erosions, those under 50 at onset, and all females. Relationships were consistently stronger with Dw4 than with DR4. Another D-related specificity, MT3, was positively correlated and Dw2/DR2 negatively correlated with erosions.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Arthritis, Rheumatoid / diagnostic imaging
  • Arthritis, Rheumatoid / immunology*
  • Epitopes
  • Female
  • HLA-DR Antigens
  • HLA-DR2 Antigen
  • Histocompatibility Antigens Class II / analysis*
  • Histocompatibility Testing
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Radiography
  • Sex Factors


  • Epitopes
  • HLA-DR Antigens
  • HLA-DR2 Antigen
  • Histocompatibility Antigens Class II