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. 1984 Apr;50(1):280-3.
doi: 10.1128/JVI.50.1.280-283.1984.

Neoplastic transformation by E26 leukemia virus is mediated by a single protein containing domains of gag and myb genes

K H Klempnauer, J M Bishop

Neoplastic transformation by E26 leukemia virus is mediated by a single protein containing domains of gag and myb genes

K H Klempnauer et al. J Virol. 1984 Apr.

Abstract

The genome of avian leukemia virus E26 shares homology with v-myb, the oncogene of avian myeloblastosis virus, and encodes a protein with an Mr of 135,000. Analyses of tryptic oligopeptides show that this protein is related to the proteins encoded by gag (Pr76gag) as well as v-myb (p45v-myb[AMV] ) and c-myb (p75c-myb). We found no evidence for the existence of additional myb-related proteins or subgenomic species of myb-related RNA in myeloblasts transformed by strain E26.

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