Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

Nature. 1984 Mar 8-14;308(5955):149-53. doi: 10.1038/308149a0.

Abstract

Of 10 distinct cloned DNA copies of mRNAs expressed in T lymphocytes but not in B lymphocytes and associated with membrane-bound polysomes, one hybridizes to a region of the genome that has rearranged in a T-cell lymphoma and several T-cell hybridomas. These characteristics suggest that it encodes one chain of the elusive antigen receptor on the surface of T lymphocytes.

MeSH terms

  • Animals
  • B-Lymphocytes / immunology
  • Cell Membrane / immunology
  • Cloning, Molecular*
  • DNA / isolation & purification*
  • Genes
  • Liver / immunology
  • Mice
  • Mice, Inbred Strains
  • Nucleic Acid Hybridization
  • Poly A / genetics
  • Polyribosomes / metabolism
  • RNA / genetics
  • RNA, Messenger / genetics
  • Receptors, Antigen, T-Cell / genetics*
  • T-Lymphocytes / immunology*

Substances

  • RNA, Messenger
  • Receptors, Antigen, T-Cell
  • Poly A
  • RNA
  • DNA