A genetic marker of human IgE heavy chains, Em(1)

Vox Sang. 1984;46(4):195-206. doi: 10.1111/j.1423-0410.1984.tb00075.x.


A monoclonal anti-IgE antibody was obtained that reacted with some IgE myeloma proteins and with all but a few normal sera. Family studies proved that a genetic marker of IgE had been detected. This allotype, called Em(1), segregates in association with certain Gm-Am haplotypes. The available quantitative evidence warrants the conclusion that human IgE has genetic variants, but no subclasses. Samples from various populations of five continents, representative for the respective prevalent Gm-Am haplotypes, were tested for Em(1). Em(1) was absent mainly in haplotypes carrying A2m(2) and G2m(n). These closely linked genes are located in a chromosomal region that comprises the gamma 2-gamma 4-epsilon-alpha 2 CH genes. A hypothesis for the generation of Em(1) is given.

MeSH terms

  • Africa
  • Americas
  • Animals
  • Asia
  • Australia
  • Child
  • Europe
  • Female
  • Genetic Linkage
  • Genetics, Population
  • Gorilla gorilla
  • Haploidy
  • Humans
  • Immunoglobulin A / genetics
  • Immunoglobulin Allotypes / genetics*
  • Immunoglobulin E / genetics*
  • Immunoglobulin G / genetics
  • Immunoglobulin Heavy Chains / genetics*
  • Male
  • Pan troglodytes
  • Pongo pygmaeus


  • Immunoglobulin A
  • Immunoglobulin Allotypes
  • Immunoglobulin G
  • Immunoglobulin Heavy Chains
  • Immunoglobulin E