Effects of cordycepin on the synthesis of nuclear and cytoplasmic RNAs in embryonic cells of Xenopus laevis

Cell Struct Funct. 1983 Dec;8(4):347-56. doi: 10.1247/csf.8.347.

Abstract

Effects of cordycepin on the incorporation of [3H] guanosine into embryonic Xenopus cells were examined. Cordycepin inhibited the labeling not only of poly(A) + RNA, but of all the other major classes of RNAs. Cellular fractionation showed that this inhibition was much stronger in the labeling of cytoplasmic RNAs than of nuclear RNAs. [3H]Cordycepin was incorporated into both poly(A) + RNA and other RNA species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Transport / drug effects
  • Cell Nucleus / metabolism
  • Cytosol / metabolism
  • Deoxyadenosines / pharmacology*
  • Embryo, Nonmammalian
  • Poly A / metabolism
  • RNA / biosynthesis*
  • RNA / metabolism
  • RNA Processing, Post-Transcriptional / drug effects
  • Transcription, Genetic / drug effects*
  • Xenopus laevis

Substances

  • Deoxyadenosines
  • Poly A
  • RNA