Subcutaneous pseudosarcomatous polyvinylpyrrolidone granuloma

Am J Surg Pathol. 1984 May;8(5):393-8. doi: 10.1097/00000478-198405000-00008.


A 77-year-old man developed an induration of the buttock following repeated injections of an antihypertensive remedy containing polyvinylpyrrolidone (PVP). The excised tumor had a cellular, pseudosarcomatous appearance with abundant extracellular material, and resembled a myxoid liposarcoma. All of the staining reactions and infra-red spectrophotometry of the deposition indicated the presence of PVP. The awareness of such a cellular PVP granuloma is important for surgical pathologists so as to avoid the diagnosis of sarcoma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Buttocks
  • Diagnosis, Differential
  • Granuloma / chemically induced*
  • Granuloma / diagnosis
  • Granuloma / pathology
  • Humans
  • Injections, Subcutaneous
  • Liposarcoma / diagnosis*
  • Liposarcoma / pathology
  • Male
  • Microscopy, Electron
  • Povidone / administration & dosage
  • Povidone / adverse effects*
  • Povidone / analysis
  • Spectrophotometry, Infrared
  • Staining and Labeling


  • Povidone