Coexistence of immunoreactive substance P and serotonin in neurones of the gut

Brain Res. 1984 Jun 8;302(2):379-82. doi: 10.1016/0006-8993(84)90253-1.


Serotonin (5-HT) and substance P (SP) were visualized by indirect immunofluorescence using two fluorochromes applied sequentially on the same preparation of myenteric plexus from the guinea pig gut. Three groups of labelled neurones were found: (i) neurones with 5-HT-like immunoreactivity only; (ii) neurones with SP-like immunoreactivity only; (iii) neurones with both 5-HT- and SP-like immunoreactivity, which represented approximately one-third of the 5-HT-like immunoreactive neurones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Colon / innervation*
  • Fluorescent Antibody Technique
  • Guinea Pigs
  • Myenteric Plexus / metabolism*
  • Neurons / metabolism
  • Serotonin / metabolism*
  • Substance P / metabolism*


  • Serotonin
  • Substance P