Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat

Invasion Metastasis. 1983;3(3):151-9.

Abstract

The growth rate (studied by mean tumor dry weight) and vascularization (studied by microangiography) of two transplantable rat tumors, a 20-methylcholanthrene-induced fibrosarcoma and a hepatoma, were significantly reduced by three prostaglandin synthesis inhibitors, indomethacin, diclofenac-sodium and aspirin, irrespective of whether the drugs were administered early or late during tumor growth.

MeSH terms

  • Animals
  • Aspirin / pharmacology
  • Diclofenac / pharmacology
  • Fibrosarcoma / blood supply
  • Fibrosarcoma / pathology
  • Indomethacin / pharmacology
  • Liver Neoplasms, Experimental / blood supply
  • Liver Neoplasms, Experimental / pathology
  • Neoplasm Transplantation
  • Neoplasms, Experimental / blood supply
  • Neoplasms, Experimental / pathology*
  • Neovascularization, Pathologic / pathology*
  • Prostaglandin Antagonists / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Sarcoma, Experimental / blood supply
  • Sarcoma, Experimental / pathology

Substances

  • Prostaglandin Antagonists
  • Diclofenac
  • Aspirin
  • Indomethacin