Substance P in the rat parotid gland: evidence for a dual origin from the otic and trigeminal ganglia

Brain Res. 1984 Jun 25;304(2):392-6. doi: 10.1016/0006-8993(84)90346-9.


The substance P innervation of the rat parotid was investigated using retrograde tracing with the fluorescent dye True Blue, in combination with the immunohistochemical localization of substance P. Retrogradely-labelled cells were seen in the otic, trigeminal, superior cervical and nodose ganglia. A proportion of the True Blue-labelled cells in the otic and trigeminal ganglia also contained substance P-like immunoreactivity providing direct evidence for a dual origin of substance P in the rat parotid. In addition, these results imply that in the rat otic ganglion substance P and acetylcholine coexist.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autonomic Fibers, Postganglionic / metabolism
  • Female
  • Ganglia, Parasympathetic / metabolism
  • Male
  • Nodose Ganglion / metabolism
  • Parasympathetic Nervous System / metabolism
  • Parotid Gland / innervation*
  • Rats
  • Rats, Inbred Strains
  • Substance P / metabolism*
  • Trigeminal Nerve / metabolism*


  • Substance P