Absorption of nicotine from small cigars

Clin Pharmacol Ther. 1978 Feb;23(2):143-51. doi: 10.1002/cpt1978232143.


The absorption of nicotine from cigars was measured in 7 male subjects who each smoked a single small cigar containing 14C-nicotine. The proportion of nicotine in the mainstream smoke delivered to the smoker's mouth was greater than that observed for cigarettes, but the proportion of nicotine in the cigar smoke which was retained by the smoker was about the same. The total dose of nicotine retained varied between 1 and 4.5 mg. Arterial plasma concentrations of nicotine were as high as those achieved by cigarette smoking but rose more slowly. Some nicotine from small cigars is absorbed by inhalation of the smoke into the lungs and some by buccal absorption.

MeSH terms

  • Absorption
  • Adult
  • Cotinine / blood
  • Heart Rate
  • Humans
  • Male
  • Middle Aged
  • Nicotine / blood
  • Nicotine / metabolism*
  • Respiration
  • Smoking / metabolism*
  • Smoking / physiopathology
  • Time Factors


  • Nicotine
  • Cotinine