Serum Alpha Fetoprotein Heterogeneity as a Means of Differentiating Between Primary Hepatocellular Carcinoma and Hepatic Secondaries

Clin Chim Acta. 1984 Jun 13;139(3):313-6. doi: 10.1016/0009-8981(84)90277-8.

Abstract

The concanavalin A binding characteristics of serum alpha-fetoprotein (AFP) were investigated in patients with primary hepatocellular carcinoma and hepatic secondaries using affinity column chromatography and radioimmunoassay. The primary hepatocellular carcinoma (n = 21) was associated with a median concanavalin A non-reactive AFP fraction of 7.4% (range 1.6 - 18.8) while the hepatic secondaries (n = 8) had a median concanavalin A non-reactive AFP fraction of 50.7% (range 26.6 - 91.7). A simple diagnostic test for differentiating between the two groups of patients is proposed.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Carcinoma, Hepatocellular / blood
  • Carcinoma, Hepatocellular / diagnosis*
  • Chromatography, Affinity
  • Concanavalin A
  • Diagnosis, Differential
  • Female
  • Humans
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / secondary*
  • Male
  • Middle Aged
  • Neoplasm Metastasis / diagnosis
  • alpha-Fetoproteins / analysis*

Substances

  • alpha-Fetoproteins
  • Concanavalin A