T lymphocyte lines induce autoimmune encephalomyelitis, delayed hypersensitivity and bystander encephalitis or arthritis

Eur J Immunol. 1984 Aug;14(8):729-34. doi: 10.1002/eji.1830140811.


Lines of rat T lymphocytes responsive to the basic protein of myelin (BP) or to the purified protein derivative of Mycobacterium tuberculosis (PPD) were inoculated i.v. into recipient rats. As reported previously, the anti-BP line cells, but not the anti-PPD line cells spontaneously accumulated in the central nervous system and caused encephalomyelitis. However, the anti-PPD line cells could be induced to enter the brain and cause bystander encephalitis by intracerebral inoculation of PPD. Anti-PPD or anti-BP line cells could mediate delayed-type hypersensitivity skin reactions or bystander arthritis elicited by specific antigen. The lines did not cause specific cytolysis in vitro. Susceptibility to delayed-type hypersensitivity or bystander disease was long lasting in rats inoculated with anti-PPD line cells, while rats inoculated with anti-BP line cells were susceptible for only a few days. Thus, lines of T lymphocytes can mediate a variety of pathological reactions directed by the presence of specific antigen, self or foreign.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Arthritis / etiology*
  • Cell Line
  • Cytotoxicity, Immunologic
  • Dermatitis, Atopic / etiology*
  • Encephalitis / etiology*
  • Encephalomyelitis, Autoimmune, Experimental / etiology*
  • Encephalomyelitis, Autoimmune, Experimental / immunology
  • Female
  • Hypersensitivity, Delayed / etiology*
  • Injections, Intradermal
  • Macrophages / immunology
  • Male
  • Myelin Basic Protein / administration & dosage
  • Rats
  • Rats, Inbred Lew
  • Skin Tests
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / transplantation
  • Tuberculin / administration & dosage


  • Myelin Basic Protein
  • Tuberculin