Ovarian Sertoli-Leydig cell tumor with retiform and heterologous components. Report of a case with hepatocytic differentiation and elevated serum alpha-fetoprotein

Am J Surg Pathol. 1984 Sep;8(9):709-18. doi: 10.1097/00000478-198409000-00011.


A 13-year-old girl had an ovarian Sertoli-Leydig cell tumor associated with marked elevation of the serum alpha-fetoprotein level. On microscopic examination, the tumor had a predominantly retiform pattern and in addition contained heterologous elements in the form of mucinous epithelium, skeletal muscle, and liver cells; alpha-fetoprotein was demonstrated within the liver cells by immunohistochemical techniques. The serum alpha-fetoprotein level fell postoperatively, but rose again when the tumor recurred. Despite radiation therapy and chemotherapy, the tumor pursued a rapidly malignant course and the patient died 9 months postoperatively.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Histocytochemistry
  • Humans
  • Immunoenzyme Techniques
  • Leydig Cell Tumor / metabolism
  • Leydig Cell Tumor / pathology*
  • Leydig Cell Tumor / surgery
  • Liver / metabolism
  • Liver / pathology
  • Microscopy, Electron
  • Neoplasm Recurrence, Local / metabolism
  • Ovarian Neoplasms / metabolism
  • Ovarian Neoplasms / pathology*
  • Ovarian Neoplasms / surgery
  • Sertoli Cell Tumor / metabolism
  • Sertoli Cell Tumor / pathology*
  • Sertoli Cell Tumor / surgery
  • alpha-Fetoproteins / analysis*


  • alpha-Fetoproteins