Acting mechanisms of Lentinan in human--II. Enhancement of non-specific cell-mediated cytotoxicity as an interferon inducer

Int J Immunopharmacol. 1984;6(4):373-9. doi: 10.1016/0192-0561(84)90057-2.

Abstract

The immunopotentiator "Lentinan" augmented the cell-mediated cytotoxicity in humans. (a) The activation of killer T cells by the mixed lymphocyte culture was accelerated only when responder cells were mixed with both a suboptimum number of stimulator cells and Lentinan. (b) The interferon level in the peripheral blood circulation of cancer patients was elevated in 12 h following Lentinan administration, and natural killer activity of peripheral mononuclear cells was enhanced in 48 h. These data indicate that Lentinan favorably affects the host mechanisms of man.

MeSH terms

  • Adenoma, Bile Duct / metabolism
  • Adjuvants, Immunologic / pharmacology*
  • Adult
  • Aged
  • Cytotoxicity, Immunologic / drug effects*
  • Female
  • Humans
  • In Vitro Techniques
  • Interferon Inducers / pharmacology*
  • Interferons / analysis
  • Interferons / pharmacology
  • Interferons / physiology
  • Killer Cells, Natural / immunology
  • Lentinan / pharmacology*
  • Male
  • Middle Aged
  • Polysaccharides / pharmacology*

Substances

  • Adjuvants, Immunologic
  • Interferon Inducers
  • Polysaccharides
  • Lentinan
  • Interferons