Effect of neonatal treatment with capsaicin on carrageenan-induced paw oedema in the rat

Naunyn Schmiedebergs Arch Pharmacol. 1984 Jul;326(4):340-2. doi: 10.1007/BF00501439.


The time course of the paw oedema induced by the subplantar injection of carrageenan was studied in rats treated neonatally with capsaicin and in their vehicle-treated controls. In the capsaicin-treated rats, which show a permanent deficit of unmyelinated primary sensory neurones, carrageenan produced an oedema which was larger and lasted longer than in the vehicle-treated rats. Pretreatment with the histamine liberator compound 48/80 reduced the carrageenan-induced paw oedema only in the capsaicin-treated rats whereas pretreatment with indomethacin reduced it in both groups of rats. The increased and prolonged inflammatory response to carrageenan in capsaicin-treated rats may be explained by an enhanced release of histamine from mast cells and may also reflect a 'trophic disorder of the denervated skin'.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Capsaicin / pharmacology*
  • Carrageenan
  • Edema / chemically induced
  • Edema / physiopathology*
  • Histamine Release / drug effects*
  • Indomethacin / pharmacology
  • Male
  • Rats
  • Rats, Inbred Strains
  • Time Factors
  • p-Methoxy-N-methylphenethylamine / pharmacology


  • p-Methoxy-N-methylphenethylamine
  • Carrageenan
  • Capsaicin
  • Indomethacin