Abstract
The ability of substance P analogues to inhibit the action of bombesin in the CNS was investigated using receptor binding and biological assays. The putative substance P antagonists inhibited binding to central receptors for both substance P and bombesin-like peptides. Spantide, which was the most potent analogue tested, reversed the bombesin induced hypothermia and grooming. Therefore the putative substance P antagonists may also antagonize the actions of bombesin in the CNS.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Body Temperature Regulation / drug effects
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Bombesin / antagonists & inhibitors*
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Brain / drug effects
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Brain / metabolism
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Grooming / drug effects
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Male
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Peptides / antagonists & inhibitors*
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Physalaemin / pharmacology
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Rats
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Receptors, Bombesin
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Receptors, Cell Surface / metabolism
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Receptors, Neurokinin-1
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Receptors, Neurotransmitter / metabolism
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Substance P / analogs & derivatives*
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Substance P / pharmacology
Substances
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Peptides
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Receptors, Bombesin
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Receptors, Cell Surface
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Receptors, Neurokinin-1
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Receptors, Neurotransmitter
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Physalaemin
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Substance P
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substance P, Pro(2)-Phe(7)-Trp(9)-
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substance P, prolyl(2)-tryptophan(7,9)-
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spantide
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Bombesin