The antagonism of bombesin in the CNS by substance P analogues

Life Sci. 1984 Nov 5;35(19):1963-9. doi: 10.1016/0024-3205(84)90477-6.

Abstract

The ability of substance P analogues to inhibit the action of bombesin in the CNS was investigated using receptor binding and biological assays. The putative substance P antagonists inhibited binding to central receptors for both substance P and bombesin-like peptides. Spantide, which was the most potent analogue tested, reversed the bombesin induced hypothermia and grooming. Therefore the putative substance P antagonists may also antagonize the actions of bombesin in the CNS.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Body Temperature Regulation / drug effects
  • Bombesin / antagonists & inhibitors*
  • Brain / drug effects
  • Brain / metabolism
  • Grooming / drug effects
  • Male
  • Peptides / antagonists & inhibitors*
  • Physalaemin / pharmacology
  • Rats
  • Receptors, Bombesin
  • Receptors, Cell Surface / metabolism
  • Receptors, Neurokinin-1
  • Receptors, Neurotransmitter / metabolism
  • Substance P / analogs & derivatives*
  • Substance P / pharmacology

Substances

  • Peptides
  • Receptors, Bombesin
  • Receptors, Cell Surface
  • Receptors, Neurokinin-1
  • Receptors, Neurotransmitter
  • Physalaemin
  • Substance P
  • substance P, Pro(2)-Phe(7)-Trp(9)-
  • substance P, prolyl(2)-tryptophan(7,9)-
  • spantide
  • Bombesin