A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes

Nature. 1984 Nov;312(5989):36-40. doi: 10.1038/312036a0.


In addition to the two previously identified genes rearranged and expressed in a cytotoxic T-lymphocyte clone, we have identified a third gene that is also rearranged and expressed in the same clone. This new gene shows clonal diversity, codes for a polypeptide chain that contains immunoglobulin-like variable and constant domains, carries potential N-glycosylation sites and is a particularly attractive candidate for the gene that encodes the alpha-subunit of the heterodimeric antigen receptor of this T-cell clone.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Line
  • Clone Cells
  • Cloning, Molecular*
  • DNA / analysis
  • Genes*
  • Humans
  • Immunoglobulins / genetics
  • Macromolecular Substances
  • Mice
  • Poly A / genetics
  • RNA / genetics
  • RNA, Messenger
  • Receptors, Antigen, T-Cell / genetics*
  • T-Lymphocytes, Cytotoxic / immunology*
  • Transcription, Genetic


  • Immunoglobulins
  • Macromolecular Substances
  • RNA, Messenger
  • Receptors, Antigen, T-Cell
  • Poly A
  • RNA
  • DNA

Associated data

  • GENBANK/X01134