CA125 antigen levels in obstetric and gynecologic patients

Obstet Gynecol. 1984 Nov;64(5):703-7.

Abstract

An immunoradiometric assay using a monoclonal antibody detects an antigenic determinant (CA125) that is present in more than 80% of epithelial ovarian cancers. CA125 levels are elevated in the sera of 16% of women in the first trimester of pregnancy and is found in very high concentration in amniotic fluid. In 988 nonpregnant patients with benign gynecologic disorders, CA125 was greater than 65 U/mL in 1% on a single determination and in 0.5% with two determinations. Given the low rate of positivity in benign gynecologic disease, the CA125 assay may deserve further evaluation for the early detection of ovarian carcinoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Amniotic Fluid / immunology
  • Antibodies, Monoclonal / immunology
  • Antigens, Neoplasm / analysis*
  • Antigens, Tumor-Associated, Carbohydrate
  • Epitopes / analysis*
  • Female
  • Genital Diseases, Female / immunology*
  • Humans
  • Middle Aged
  • Ovarian Neoplasms / immunology
  • Pregnancy*
  • Radioimmunoassay

Substances

  • Antibodies, Monoclonal
  • Antigens, Neoplasm
  • Antigens, Tumor-Associated, Carbohydrate
  • Epitopes