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Review
, 6 (5), 619-24

Capsular Polysaccharides of Cryptococcus Neoformans

Review

Capsular Polysaccharides of Cryptococcus Neoformans

A K Bhattacharjee et al. Rev Infect Dis.

Abstract

Polysaccharides of Cryptococcus neoformans are considered to have a role in the virulence of this encapsulated fungus. The structure has been determined for the most abundant polysaccharide, a glucuronoxylomannan of varying xylose and ester content. The structural complexity of the capsular material increases from serotype D to A to B to C, but even for the simplest capsule (type D), the immunodeterminants seem to occur only on the side chains. The interactions of some of these groups with antibodies is discussed.

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