Capsular polysaccharides of Cryptococcus neoformans

Rev Infect Dis. Sep-Oct 1984;6(5):619-24. doi: 10.1093/clinids/6.5.619.

Abstract

Polysaccharides of Cryptococcus neoformans are considered to have a role in the virulence of this encapsulated fungus. The structure has been determined for the most abundant polysaccharide, a glucuronoxylomannan of varying xylose and ester content. The structural complexity of the capsular material increases from serotype D to A to B to C, but even for the simplest capsule (type D), the immunodeterminants seem to occur only on the side chains. The interactions of some of these groups with antibodies is discussed.

Publication types

  • Review

MeSH terms

  • Antibodies, Fungal / immunology
  • Antigen-Antibody Reactions
  • Antigens, Fungal / immunology
  • Carbohydrate Sequence
  • Cryptococcus / analysis*
  • Cryptococcus neoformans / analysis*
  • Cryptococcus neoformans / classification
  • Cryptococcus neoformans / immunology
  • Epitopes / immunology
  • Mannans / analysis
  • Polysaccharides / analysis*
  • Polysaccharides / immunology
  • Serotyping

Substances

  • Antibodies, Fungal
  • Antigens, Fungal
  • Epitopes
  • Mannans
  • Polysaccharides
  • glucuronoxylomannan