Immune functions of human synovial cells. Phenotypic and T cell regulatory properties of macrophage-like cells that express HLA-DR

Arthritis Rheum. 1982 May;25(5):488-501. doi: 10.1002/art.1780250502.


Normal and rheumatoid synovial cells have been analyzed in frozen sections and in suspension. HLA-DR-expressing, macrophage-like cells are demonstrated in normal synovial intima and in rheumatoid tissue. Suspended normal synoviocytes equaled peripheral blood non-T lymphocytes as stimulators of mixed lymphocyte reactions, whereas adherent rheumatoid synovial cells were extremely efficient as such stimulators and in presenting soluble antigens to autologous T lymphocytes. This HLA-DR-dependent T lymphocyte regulation might provide a cellular basis for the HLA-D haplotype-arthritis associations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal / immunology
  • Arthritis, Rheumatoid / immunology
  • Arthritis, Rheumatoid / pathology
  • Esterases / biosynthesis
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II / immunology*
  • Humans
  • Lymphocyte Culture Test, Mixed
  • Macrophages / immunology*
  • Phenotype
  • Receptors, Fc / immunology
  • Synovial Membrane / cytology
  • Synovial Membrane / enzymology
  • Synovial Membrane / immunology*
  • Synovial Membrane / pathology
  • T-Lymphocytes / immunology*


  • Antibodies, Monoclonal
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II
  • Receptors, Fc
  • Esterases