Abstract
A new X-linked recessive lymphoproliferative syndrome has variable phenotypes: fatal infectious mononucleosis (I.M.), agammaglobulinaemia after I.M., American Burkitt's lymphoma, histiocytic lymphoma, immunoblastic sarcoma of B cells, or plasmacytoma. An immunodeficiency to rubeola and the Epstein-Barr virus probably ensues from the mutant gene. The phenotypes (spectrum of B-cell disorders) have a common inheritance and the aetiology is similar.
MeSH terms
-
Adolescent
-
Adult
-
Agammaglobulinemia / etiology
-
Agammaglobulinemia / genetics
-
B-Lymphocytes* / immunology
-
Child
-
Child, Preschool
-
Female
-
Herpesvirus 4, Human / immunology
-
Humans
-
Immunologic Deficiency Syndromes / complications
-
Infant
-
Infectious Mononucleosis / etiology
-
Infectious Mononucleosis / genetics
-
Lymphoma* / etiology
-
Lymphoma* / genetics
-
Lymphoma, Large B-Cell, Diffuse / genetics
-
Lymphoma, Large B-Cell, Diffuse / immunology
-
Male
-
Phenotype
-
Plasmacytoma / etiology
-
Plasmacytoma / genetics
-
Sarcoma / etiology
-
Sarcoma / genetics
-
Sex Chromosome Aberrations / complications
-
Syndrome