Familial rheumatoid arthritis: a kindred identified through a proband with seronegative juvenile arthritis includes members with seropositive, adult-onset disease

Hum Immunol. 1982 Jun;4(3):183-96. doi: 10.1016/0198-8859(82)90034-9.


Segregation of chromosome #6 markers has been studied in a large family, identified by a proband with seronegative, juvenile-onset rheumatoid arthritis, which contains four other individuals with adult-onset rheumatoid arthritis (RA). Two of the adult-onset patients have classical seropositive RA. Sera from two healthy members of this family also contain rheumatoid factors (RF). Six family members had crossovers in the short arm of chromosome #6. Three individuals with recombinants between HLA-B and HLA-D were identified; three others had identifiable crossovers between HLA-D and GLO (Glyoxylase 1). Linkage analysis suggested that susceptibility to RA in this family was influenced by a dominant gene located centromeric to HLA-B. The highest lod score (1.64) was obtained for linkage to GLO at a recombination rate of zero. Inheritance of specific chromosome #6 or Gm immunoglobulin allotype markers did not appear to influence serum RF. These results agree with previous family studies which suggest that acquisition of childhood- and adult-onset RA is influenced by a common disease susceptibility gene, linked to the major histocompatibility gene complex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Antinuclear / genetics
  • Antigen-Antibody Complex / genetics
  • Arthritis, Juvenile / diagnosis
  • Arthritis, Juvenile / genetics*
  • Arthritis, Juvenile / immunology
  • Arthritis, Rheumatoid / diagnosis
  • Arthritis, Rheumatoid / genetics*
  • Arthritis, Rheumatoid / immunology
  • Child, Preschool
  • Female
  • Genes, MHC Class II
  • Genetic Linkage
  • HLA-DR Antigens
  • Histocompatibility Testing
  • Humans
  • Lymphocyte Culture Test, Mixed
  • Male
  • Middle Aged
  • Pedigree
  • Rheumatoid Factor / genetics


  • Antibodies, Antinuclear
  • Antigen-Antibody Complex
  • HLA-DR Antigens
  • Rheumatoid Factor