Abstract
1. The accumulation of p-chlorophenylethylamine (pCPE) in rat brain after administration of pargyline plus p-chlorophenylalanine (pCPA) is demonstrated. 2. Measurements of pCPE in brain were performed at 0.25 h, 1 h and 4 h after administration of pCPA to pargyline-pretreated rats, and amounts of pCPE were shown to increase with time.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain / drug effects*
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Brain / metabolism
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Dose-Response Relationship, Drug
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Fenclonine / pharmacology*
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Male
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Pargyline / pharmacology*
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Phenethylamines / metabolism*
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Rats
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Rats, Inbred Strains
Substances
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Phenethylamines
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4-chlorophenethylamine
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Pargyline
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Fenclonine