Para-chlorophenylethylamine in brains of rats treated with a monoamine oxidase inhibitor and p-chlorophenylalanine

Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(4-6):343-6. doi: 10.1016/s0278-5846(82)80103-6.

Abstract

1. The accumulation of p-chlorophenylethylamine (pCPE) in rat brain after administration of pargyline plus p-chlorophenylalanine (pCPA) is demonstrated. 2. Measurements of pCPE in brain were performed at 0.25 h, 1 h and 4 h after administration of pCPA to pargyline-pretreated rats, and amounts of pCPE were shown to increase with time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / drug effects*
  • Brain / metabolism
  • Dose-Response Relationship, Drug
  • Fenclonine / pharmacology*
  • Male
  • Pargyline / pharmacology*
  • Phenethylamines / metabolism*
  • Rats
  • Rats, Inbred Strains

Substances

  • Phenethylamines
  • 4-chlorophenethylamine
  • Pargyline
  • Fenclonine