Polymorphonuclear neutrophils express the common acute lymphoblastic leukemia antigen

J Exp Med. 1983 Mar 1;157(3):1064-9. doi: 10.1084/jem.157.3.1064.

Abstract

Monoclonal antibodies J5, VIL-A1, and BA-3, known to react with the common acute lymphoblastic leukemia antigen (CALLA) were found to specifically stain normal human polymorphonuclear neutrophils (PMN). The antigen detected on PMN had a molecular weight (95,000-110,000 mol wt) close to that of CALLA (95,000-100,000 mol wt) and thus these surface membrane antigens are likely related, if not identical. The fluorescent staining intensity of PMN is comparable to that of CALLA-positive leukemic cells and the presence of PMN in patient samples could potentially produce false-positive results in diagnosis.

MeSH terms

  • Adult
  • Animals
  • Antibodies, Monoclonal / immunology
  • Antigens, Neoplasm / analysis*
  • Antigens, Neoplasm / immunology
  • False Positive Reactions
  • Fluorescent Antibody Technique
  • Humans
  • Leukemia, Lymphoid / diagnosis
  • Leukemia, Lymphoid / immunology*
  • Lymphoma / immunology
  • Mice
  • Neprilysin
  • Neutrophils / immunology*

Substances

  • Antibodies, Monoclonal
  • Antigens, Neoplasm
  • Neprilysin