Histological findings following oestrogen treatment of hereditary haemorrhagic telangiectasia. A controlled double-blind investigation

J Laryngol Otol. 1983 May;97(5):427-9. doi: 10.1017/s0022215100094354.


In a controlled investigation of 22 patients with hereditary haemorrhagic telangiectasia, an evaluation has been carried out of the connective tissue content of muco-substances prior to and after treatment with oral oestrogen (oestradiol valerate 4 mg. daily). The clinical condition of the patients, all of whom had haemorrhagic anaemia, was evaluated by the frequency of epistaxis and by blood analyses. No effect of treatment could be demonstrated by means of histochemical, clinical or laboratory methods.

MeSH terms

  • Adult
  • Aged
  • Connective Tissue / analysis
  • Double-Blind Method
  • Estradiol / analogs & derivatives*
  • Estradiol / therapeutic use
  • Female
  • Glycosaminoglycans / analysis
  • Histocytochemistry
  • Humans
  • Lip / analysis
  • Male
  • Middle Aged
  • Telangiectasia, Hereditary Hemorrhagic / drug therapy*
  • Telangiectasia, Hereditary Hemorrhagic / metabolism


  • Glycosaminoglycans
  • Estradiol