The control of mammalian cell proliferation by growth factors, basement lamina, and lipoproteins

J Invest Dermatol. 1983 Jul;81(1 Suppl):40s-50s. doi: 10.1111/1523-1747.ep12540453.

Abstract

The effect of growth factors such as fibroblast growth factor on the production of a basement lamina by cultured endothelial cells has been investigated. The ability of these cells to grow and differentiate properly correlated with their ability to produce a basement lamina. The effect of such a substrate on the growth, differentiation, and aging of cells in vitro, as well as its use for the long-term culture of either normal diploid cells or tumor cells, is reviewed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Basement Membrane / ultrastructure
  • Cell Adhesion / drug effects
  • Cell Differentiation / drug effects
  • Cell Division / drug effects
  • Cell Survival / drug effects
  • Endothelium / cytology*
  • Epidermal Growth Factor / pharmacology
  • Fibroblast Growth Factors
  • Growth Substances / pharmacology*
  • Humans
  • Hydroxymethylglutaryl CoA Reductases / metabolism
  • Lipoproteins / pharmacology*
  • Lovastatin* / analogs & derivatives*
  • Naphthalenes / pharmacology
  • Neurons / cytology
  • Peptides / pharmacology

Substances

  • Growth Substances
  • Lipoproteins
  • Naphthalenes
  • Peptides
  • mevastatin
  • Fibroblast Growth Factors
  • Epidermal Growth Factor
  • Lovastatin
  • Hydroxymethylglutaryl CoA Reductases