Abstract
The effect of growth factors such as fibroblast growth factor on the production of a basement lamina by cultured endothelial cells has been investigated. The ability of these cells to grow and differentiate properly correlated with their ability to produce a basement lamina. The effect of such a substrate on the growth, differentiation, and aging of cells in vitro, as well as its use for the long-term culture of either normal diploid cells or tumor cells, is reviewed.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Basement Membrane / ultrastructure
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Cell Adhesion / drug effects
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Cell Differentiation / drug effects
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Cell Division / drug effects
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Cell Survival / drug effects
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Endothelium / cytology*
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Epidermal Growth Factor / pharmacology
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Fibroblast Growth Factors
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Growth Substances / pharmacology*
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Humans
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Hydroxymethylglutaryl CoA Reductases / metabolism
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Lipoproteins / pharmacology*
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Lovastatin* / analogs & derivatives*
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Naphthalenes / pharmacology
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Neurons / cytology
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Peptides / pharmacology
Substances
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Growth Substances
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Lipoproteins
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Naphthalenes
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Peptides
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mevastatin
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Fibroblast Growth Factors
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Epidermal Growth Factor
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Lovastatin
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Hydroxymethylglutaryl CoA Reductases